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EGFR ligand-2

CAT: 0013-GTR19235429-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19235429-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
EGFR ligand-2 (C4) is a covalent inhibitor targeting mutant EGFR, exhibiting potent activity against L858R (IC50=21 nM) and L858R/T790M (IC50=48 nM) variants. It serves as a key warhead for constructing PROTAC degraders, useful in oncology research for in vitro target validation and mechanism studies.
CAS Number
2737283-20-2
Field of Research
Cardiovascular Research, Cell Biology, Signal Transduction
Smiles
N (C=1N (C=2C (N1) =CN=C (NC3=CC=C (C=C3) N4CCN (C) CC4) N2) [C@@H]5CN (C (C=C) =O) CCC5) C6=CC=CC=C6
Molecular Formula
C30H35N9O
Molecular Weight
537.66
Storage Conditions
-20°C
Notes
For research use only.

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