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AKT-IN-2

CAT: 0804-HY-112148Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-112148Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
AKT-IN-2 is a potent, selective and orally bioavailable AKT inhibitor with an IC50 of 5 nM for AKT1[1].
CAS Number
1295514-91-8
UNSPSC
12352005
Target
Akt
Type
Reference compound
Related Pathways
PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/AKT-IN-2.html
Solubility
10 mM in DMSO
Smiles
O=C1C[C@@H](C)C2=C(N3CCC(C4=NC(CCC(F)(F)F)=CN4CCN5CCCC5)CC3)N=CN=C2N1
Molecular Formula
C25H34F3N7O
Molecular Weight
505.58
References & Citations
[1]Parthasarathy S, et al. Discovery of chiral dihydropyridopyrimidinones as potent, selective and orally bioavailable inhibitors of AKT. Bioorg Med Chem Lett. 2018 Jun 1;28 (10) :1887-1891.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Akt1

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