GR 113808

• Description:

  GR 113808 is a potent and highly selective 5-HT4 receptor antagonist (pKb= 8.8) . GR 113808 shows 300-fold selectivity over 5-HT1A, 5-HT1B, 5-HT2A, 5-HT2C and 5-HT3 receptors[1].

• UNSPSC:

  12352005

• Target:

  5-HT Receptor

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein; Neuronal Signaling

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology; Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/gr-113808.html

• Purity:

  99.96

• Solubility:

  DMSO : 39 mg/mL (ultrasonic; warming)

• Smiles:

  O=C(C1=CN(C)C2=C1C=CC=C2)OCC3CCN(CCNS(=O)(C)=O)CC3

• Molecular Formula:

  C19H27N3O4S

• Molecular Weight:

  393.50

• References & Citations:

  [1]Gale JD, et al. GR113808: a novel, selective antagonist with high affinity at the 5-HT4 receptor.Br J Pharmacol. 1994 Jan;111 (1) :332-8.|[2]Spohn SN, et al.Protective Actions of Epithelial 5-Hydroxytryptamine 4 Receptors in Normal and Inflamed Colon.Gastroenterology. 2016 Nov;151 (5) :933-944.e3.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C (Powder, sealed storage, away from moisture)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  5-HT1 Receptor;5-HT2 Receptor; Apolipoprotein D; lactoferrin; mLAG-3; α-1 microglobulin

• CAS Number:

  [144625-51-4]