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KW-2581

CAT: 0804-HY-123868Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-123868Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
KW-2581 is a steroidal selective steroid sulfatase (STS) inhibitor with an IC50 of 4 nM. KW-2581 inhibits STS activity of ZR-75-1 cells with an IC50 of 13 nM. KW-2581 inhibits the E1S-stimulated growth of ZR-75-1 cells with an IC50 of 0.18 nM. KW-2581 inhibits sulfated-estrogen dependent growth of breast cancer cells both in vitro and in vivo. KW-2581 induced regression in E1S-induced tumor growth. KW-2581 can be studied in research on hormone receptors-positive breast cancer[1][2].
CAS Number
[284045-56-3]
UNSPSC
12352005
Target
Steroid Sulfatase
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
O=S(OC1=CC=C2[C@@]3([H])CC[C@]4(C)C(C(N(C(C)C)C(C)C)=O)=CC[C@@]4([H])[C@]3([H])CCC2=C1)(N)=O
Molecular Formula
C25H36N2O4S
Molecular Weight
460.63
References & Citations
[1]Ishida, H., et al ., (2007) . Inhibition of steroid sulfatase activity and cell proliferation in ZR-75-1 and BT-474 human breast cancer cells by KW-2581 in vitro and in vivo. Breast cancer research and treatment, 104 (2), 211-219. |[2]Ishida, H., et al., (2007) . A novel steroidal selective steroid sulfatase inhibitor KW-2581 inhibits sulfated-estrogen dependent growth of breast cancer cells in vitro and in animal models. Breast cancer research and treatment, 106 (2), 215-227.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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