PD-143188

CAT: 0804-HY-19186Size: 1 EachDry Ice: NoHazardous: No

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Description

PD-143188 (CI 1007) is a selective agonist targeting dopamine (DA) receptors, with Ki values of 25.5 nM and 16.6 nM for human D2 and D3 receptors, respectively and lower affinity for D4.2 receptors (Ki=90.9 nM) . PD-143188 inhibits DA release, synthesis and metabolism, while reducing cellular cyclic AMP levels, exerting antipsychotic activity. PD-143188 is promising for research of psychopharmacology[1].

CAS Number

150013-70-0

Product Name Alternative

CI 1007

UNSPSC

12352005

Target

Dopamine Receptor

Related Pathways

GPCR/G Protein; Neuronal Signaling

Field of Research

Neurological Disease

Smiles

C1(C2=CC=CC=C2)=CCN(C[C@H]3CC(C4=CC=CC=C4)=CCC3)CC1

Molecular Formula

C24H27N

Molecular Weight

329.48

References & Citations

[1]Rugsley TA, et al. CI-1007, a dopamine partial agonist and potential antipsychotic agent. I. Neurochemical effects. J Pharmacol Exp Ther. 1995 Aug;274 (2) :898-911.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

Phase 2

Isoform

D2 Receptor; D3 Receptor; D4 Receptor

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PD-143188

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