CI-996

CAT: 0804-HY-19165Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-19165Size:1 Each
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Description
CI-996 is a potent, selective, orally active angiotensin II (Ang II) type 1 (AT1) receptor antagonist. In rat liver membranes CI-996 displaces specifically bind [125I]Ang II with an IC50 of 0.8 nM. CI-996 has blood pressure-lowering activity[1].
CAS Number
[150438-02-1]
UNSPSC
12352005
Target
Angiotensin Receptor
Related Pathways
GPCR/G Protein
Field of Research
Cardiovascular Disease
Smiles
O=C(C1=C(N2C(C(C(F)(F)F)=O)=CC=C2)N=C(CCC)N1CC3=CC=C(C4=CC=CC=C4C5=NN=NN5)C=C3)O
Molecular Formula
C27H22F3N7O3
Molecular Weight
549.50
References & Citations
[1]Keiser JA, et al. Pharmacologic characterization of CI-996, a new angiotensin receptor antagonist. J Pharmacol Exp Ther. 1995 Mar;272 (3) :963-9.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
AT1 Receptor

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