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SCH-602539

CAT: 0804-HY-18201Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-18201Size:1 Each
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Description
SCH-602539 is a selective PAR-1 antagonist. SCH-602539 inhibits platelet aggregation in response to PAR-1-selective high-affinity thrombin receptor agonist peptide. SCH-602539 exhibits synergistic antithrombotic effects when used in combination with Cangrelor.
CAS Number
618385-42-5
UNSPSC
12352005
Target
Protease Activated Receptor (PAR)
Related Pathways
GPCR/G Protein
Field of Research
Cardiovascular Disease
Smiles
O=C(OCC)N[C@H]1C[C@@]2([H])C[C@]3([H])[C@@]([C@@H](/C=C/C4=CC=C(C5=NC=CC=C5)C=N4)[C@]2([H])CC1)([H])[C@@H](C)OC3=O
Molecular Formula
C28H33N3O4
Molecular Weight
475.58
References & Citations
[1]Chintala M, et al. SCH 602539, a protease-activated receptor-1 antagonist, inhibits thrombosis alone and in combination with cangrelor in a Folts model of arterial thrombosis in cynomolgus monkeys. Arterioscler Thromb Vasc Biol. 2010 Nov;30 (11) :2143-9.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PAR1

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