PZ-2891

• Description:

  PZ-2891 is an orally bioavailable, brain penetrant pantothenate kinase (PANK) modulator. PZ-2891 act as an orthosteric inhibitor at high concentrations and an allosteric activator at lower sub-saturating concentrations. PZ-2891 inhibits human pantothenate kinases PANK1β, PANK2, and PANK3 with IC50s of 40.2 nM, 0.7 nM and 1.3 nM, respectively[1].

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  PANK

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/PZ-2891.html

• Purity:

  99.68

• Solubility:

  DMSO : 75 mg/mL (ultrasonic)

• Smiles:

  N#CC1=NN=C (N2CCN (C (CC3=CC=C (C (C) C) C=C3) =O) CC2) C=C1

• Molecular Formula:

  C20H23N5O

• Molecular Weight:

  349.43

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Sharma LK, et al. A therapeutic approach to pantothenate kinase associated neurodegeneration. Nat Commun. 2018 Oct 23;9 (1) :4399.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  2170608-82-7