RNAP-σ interaction-IN-4

• Description :

  RNAP-σ interaction-IN-4 (Compound 3a) is an inhibitor of the RNA polymerase-sigma factor interaction (RNAP-σ) with MIC values against S. pneumoniae and S. aureus of 1 μg/mL and 2 μg/mL, respectively. RNAP-σ interaction-IN-4 exhibits strong bactericidal properties by interfering with the interaction of β′CH−σ and disrupting the transcription of bacteria. RNAP-IN-2 shows significant efficacy in sepsis models. RNAP-σ interaction-IN-4 can be used to study Gram-positive bacterial infections caused by multi-drug resistant strains[1].

• UNSPSC :

  12352100

• Target :

  Bacterial; DNA/RNA Synthesis

• Related Pathways :

  Anti-infection; Cell Cycle/DNA Damage

• Field of Research :

  Infection

• Smiles :

  ClC1=C(C=C(C=C1)SC2=C(C=C(C=C2)SC3=CC=CC=C3C(O)=O)C4=CC=CC=C4)Cl

• Molecular Formula :

  C25H16Cl2O2S2

• Molecular Weight :

  483.43

• References & Citations :

  [1]Ye J, et al. Dithioether Inhibitors of Bacterial RNA Polymerase-Sigma Factor Interactions Exhibit In Vivo Efficacy against MRSA. J Med Chem. 2025 Dec 11;68 (23) :25352-25374.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported