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RNAP-σ interaction-IN-4

CAT: 0804-HY-179637Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-179637Size:1 Each
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
RNAP-σ interaction-IN-4 (Compound 3a) is an inhibitor of the RNA polymerase-sigma factor interaction (RNAP-σ) with MIC values against S. pneumoniae and S. aureus of 1 μg/mL and 2 μg/mL, respectively. RNAP-σ interaction-IN-4 exhibits strong bactericidal properties by interfering with the interaction of β′CH−σ and disrupting the transcription of bacteria. RNAP-IN-2 shows significant efficacy in sepsis models. RNAP-σ interaction-IN-4 can be used to study Gram-positive bacterial infections caused by multi-drug resistant strains[1].
UNSPSC
12352100
Target
Bacterial; DNA/RNA Synthesis
Related Pathways
Anti-infection; Cell Cycle/DNA Damage
Field of Research
Infection
Smiles
ClC1=C(C=C(C=C1)SC2=C(C=C(C=C2)SC3=CC=CC=C3C(O)=O)C4=CC=CC=C4)Cl
Molecular Formula
C25H16Cl2O2S2
Molecular Weight
483.43
References & Citations
[1]Ye J, et al. Dithioether Inhibitors of Bacterial RNA Polymerase-Sigma Factor Interactions Exhibit In Vivo Efficacy against MRSA. J Med Chem. 2025 Dec 11;68 (23) :25352-25374.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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