RNAP-σ interaction-IN-4

CAT: 0013-GTR19274377-01Size: 50 mgDry Ice: NoHazardous: No

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CAT#:0013-GTR19274377-01Size:50 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

RNAP-σ interaction-IN-4 (Compound 3a) is an inhibitor of the interaction between RNA polymerase and the sigma factor (RNAP-σ) . It has a minimum inhibitory concentration (MIC) of 1 μg/mL against S. pneumoniae and 2 μg/mL against S. aureus. This compound exhibits potent bactericidal properties by disrupting bacterial transcription through interference with the β′CH−σ interaction. Additionally, RNAP-IN-2 has demonstrated significant efficacy in a sepsis model. RNAP-σ interaction-IN-4 is applicable for studying Gram-positive bacterial infections involving multidrug-resistant strains.

Storage Conditions

-20°C

Notes

For research use only.

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