ERCC1/XPA interaction inhibitor 1

• UNSPSC Description:

  ERCC1/XPA interaction inhibitor 1 (compound 27o) is a potent ERCC1/XPA67-80 interaction inhibitor with an EC50 value of 4.7 µM. ERCC1/XPA interaction inhibitor 1 has the potential for the research of DNA damaging agents and overcoming resistance to platinum-based chemotherapy[1].

• Target Antigen:

  DNA/RNA Synthesis

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/ercc1-xpa-interaction-inhibitor-1.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(NC1=CC=CC=C1C(O)CSC2=NC(C)=CC(C)=C2C#N)CC3=CC=C(Cl)C=C3

• Molecular Weight:

  451.97

• References & Citations:

  [1]Obermann R, et al. Small Molecule Antagonists of the DNA Repair ERCC1/XPA Protein-Protein Interaction. C ChemMedChem. 2024 Apr 16;19(8):e202300648.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported