EQ-04

• Description :

  EQ-04 is a highly selective positive allosteric modulator (PAM) of α7 nAChR. EQ-04 has no direct inhibitory activity on AChE and BChE. EQ-04 inhibits Aβ aggregation. EQ-04 has safe cytotoxicity and potent neuroprotective activity. EQ-04 can be used for the study of Alzheimer's disease.

• UNSPSC :

  12352005

• Target :

  Amyloid-β; Cholinesterase (ChE)

• Related Pathways :

  Neuronal Signaling

• Field of Research :

  Neurological Disease

• Smiles :

  N12CC(OC3=CC=C(C#CC4=CC=CC=C4)N=C3)C(CC2)CC1

• Molecular Formula :

  C20H20N2O

• Molecular Weight :

  304.39

• References & Citations :

  [1]Cavagnero PS, et al. Neuroprotective Activity of 3- ((6- (Phenylethynyl) pyridin-3-yl) oxy) quinuclidine: A Potential Ligand for the Treatment of Alzheimer's Disease. ACS Chem Neurosci. 2025 Dec 3;16 (23) :4502-4510.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  AChE