JIB-04

• UNSPSC Description:

  JIB-04 is a pan-selective Jumonji histone demethylase inihibitor with IC50s of 230, 340, 855, 445, 435, 1100, and 290 nM for JARID1A, JMJD2E, JMJD3, JMJD2A, JMJD2B, JMJD2C, and JMJD2D, respectively.

• Target Antigen:

  Apoptosis; Histone Demethylase

• Type:

  Reference compound

• Related Pathways:

  Apoptosis;Epigenetics

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/JIB-04.html

• Smiles:

  ClC1=CN=C(N/N=C(C2=CC=CC=C2)/C3=NC=CC=C3)C=C1

• Molecular Weight:

  308.76492

• References & Citations:

  [1]Wang L, et al. A small molecule modulates Jumonji histone demethylase activity and selectively inhibits cancer growth. Nat Commun, 2013. 4: p. 2035.|[2]Banelli B, et al. Small molecules targeting histone demethylase genes (KDMs) inhibit growth of temozolomide-resistant glioblastoma cells. Oncotarget. 2017 Apr 4.

• Shipping Conditions:

  Room Temperature

• CAS Number:

  199596-05-9