LC-04-045

• Description :

  LC-04-045 is a NEK7 (NIMA-related kinase 7) molecular glue degrader (MGD) . LC-04-045 demonstrates potent activity of NEK7 degradation with a DC50 (half-maximal degradation) of 7 nM and a Dmax (maximum degradation) of 90% in MOLT-4 cells. LC-04-045 displays high selectivity for NEK7 across the proteome. LC-04-045 degrades NEK7 mediated by the ubiquitin-proteasome system (UPS) and relies on the glycine 57 (G57) -containing degron motif in NEK7. LC-04-045 effectively inhibits secretion of IL-1β and IL-18 with IC50s of 33.03 nM and 32.99 nM, respectively. LC-04-045 is potential for inflammatory diseases research[1].

• UNSPSC :

  12352005

• Target :

  Interleukin Related; NEKs

• Related Pathways :

  Cell Cycle/DNA Damage; Immunology/Inflammation

• Applications :

  COVID-19-anti-virus

• Field of Research :

  Inflammation/Immunology

• Purity :

  99.56

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  O=C([C@@H](N(CC1=C2C=CC(C3=CN=C4CN(CC5=CC=CC=C5C6=CC=CC=C6Cl)CCN43)=C1)C2=O)CC7)NC7=O

• Molecular Formula :

  C32H28ClN5O3

• Molecular Weight :

  566.05

• References & Citations :

  [1]Chen L, et al. Selective and Potent Molecular Glue Degraders for NIMA-Related Kinase 7. Angew Chem Int Ed Engl. 2025 Feb 10:e202500169.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  IL-1; IL-8; NEK7