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DHODH-IN-33

CAT: 0013-GTR19273992-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19273992-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
DHODH-IN-33 is a selective DHODH inhibitor that exhibits potent activity against A549 cells (IC50 = 5.22 μM) and 5637 cells (IC50 = 3.03 μM) . It induces autophagy-dependent ferroptosis, characterized by mitochondrial dysfunction, lipid peroxidation, and accumulation of ROS, without significant toxicity in vivo. The anticancer effect of DHODH-IN-33 is achieved through promoting autophagy-dependent degradation of dihydroorotate dehydrogenase. This compound can be used in studies related to non-small cell lung cancer and bladder cancer.
CAS Number
3026839-88-0
Smiles
O=S (=O) (C1=CC=C (C=C1) C) N2C3=CC=C (OC) C=C3CC4OC=5C=CC=CC5C24
Molecular Formula
C23H21NO4S
Molecular Weight
407.48
Storage Conditions
-20°C
Notes
For research use only.

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