DIM-3,5-Cl2

• Description:

  DIM-3,5-Cl2 is an inverse NR4A1/NR4A2 agonist. DIM-3,5-Cl2 can downregulate the pro-oncogenic responses/gene products regulated by NR4A1/NR4A2. DIM-3,5-Cl2 can induce ROS, malondialdehyde, and lipoperoxide formation, and this was accompanied by decreased expression of GPX4 and SLC7A11 and induction of CD71. DIM-3,5-Cl2 can induce ferroptosis. DIM-3,5-Cl2 can be used for the study of triple-negative breast cancer[1].

• UNSPSC:

  12352005

• Target:

  Ferroptosis; Glutathione Peroxidase; Nuclear Hormone Receptor 4A/NR4A; Reactive Oxygen Species (ROS) ; Transferrin Receptor

• Related Pathways:

  Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB; Vitamin D Related/Nuclear Receptor

• Field of Research:

  Cancer

• Smiles:

  ClC1=CC(Cl)=CC(C(C2=CNC3=C2C=CC=C3)C4=CNC5=C4C=CC=C5)=C1

• Molecular Formula:

  C23H16Cl2N2

• Molecular Weight:

  391.29

• References & Citations:

  [1]Oany AR, et al. Orphan nuclear receptor 4A1 (NR4A1) and NR4A2 are endogenous regulators of CD71 and their ligands induce ferroptosis in breast cancer. Cell Death Dis. 2025 Nov 3;16 (1) :776.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  Nur77/NR4A1; Nurr1/NR4A2

• CAS Number:

  [2595179-74-9]