RegisterLogin

DIM-3,5-Cl2

CAT: 0804-HY-179528Size: 1 EachDry Ice: NoHazardous: No
CAT#: HY-179528Size: 1 Each
Selected
PRICE
AVAILABILITY
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
DIM-3,5-Cl2 is an inverse NR4A1/NR4A2 agonist. DIM-3,5-Cl2 can downregulate the pro-oncogenic responses/gene products regulated by NR4A1/NR4A2. DIM-3,5-Cl2 can induce ROS, malondialdehyde, and lipoperoxide formation, and this was accompanied by decreased expression of GPX4 and SLC7A11 and induction of CD71. DIM-3,5-Cl2 can induce ferroptosis. DIM-3,5-Cl2 can be used for the study of triple-negative breast cancer[1].
CAS Number
[2595179-74-9]
UNSPSC
12352005
Target
Ferroptosis; Glutathione Peroxidase; Nuclear Hormone Receptor 4A/NR4A; Reactive Oxygen Species (ROS) ; Transferrin Receptor
Related Pathways
Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB; Vitamin D Related/Nuclear Receptor
Field of Research
Cancer
Smiles
ClC1=CC(Cl)=CC(C(C2=CNC3=C2C=CC=C3)C4=CNC5=C4C=CC=C5)=C1
Molecular Formula
C23H16Cl2N2
Molecular Weight
391.29
References & Citations
[1]Oany AR, et al. Orphan nuclear receptor 4A1 (NR4A1) and NR4A2 are endogenous regulators of CD71 and their ligands induce ferroptosis in breast cancer. Cell Death Dis. 2025 Nov 3;16 (1) :776.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Nur77/NR4A1; Nurr1/NR4A2

Related Products

CatalogName
HY-W145116-01[Ru (phen) 3]Cl2
HY-175248PSMA-DIM
HY-128947CL2 Linker
HY-112055-01DIM-C-pPhOH
HY-126350-01CL2-SN-38
HY-145513CL2-MMT-SN38
HY-111492-01DIM-C-pPhOCH3
HY-169581DIM-C-pPhtBu
HY-W013066-01Pd (Xantphos) Cl2
HY-112056-01DIM-C-pPhCO2Me

Alternative Products

CatalogName
OR1036237-01Fmoc-Tyr (3,5-Cl2) -OH
255146DIM
6377/5DIM-C-pPhOH 5 mg
T211832-01PSMA-DIM
T17730-01CL2 Linker
MBS133214CL2 Linker
MBS5770600CL2 Linker
CSB-DT2234Fmoc-Phe (2,5-Cl2) -OH
MBS3842852-01CL2 Linker
MBS9022726-01Fmoc-Phe(2,5-Cl2)-OH

Popular Products