DIM-C-pPhOH

DIM-C-pPhOH

• CAS Number: 151358-47-3
• UNSPSC Description: DIM-C-pPhOH is a nuclear receptor 4A1 (NR4A1) antagonist. DIM-C-pPhOH inhibits cancer cell growth and mTOR signaling, induce apoptosis and cellular stress. DIM-C-pPhOH reduces cell proliferation with IC50 values of 13.6 μM and 13.0 μM for ACHN cells and 786-O cells, respectively[1].
• Target Antigen: Apoptosis; Nuclear Hormone Receptor 4A/NR4A
• Type: Reference compound
• Related Pathways: Apoptosis;Vitamin D Related/Nuclear Receptor
• Applications: Neuroscience-Neurodegeneration
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/dim-c-pphoh.html
• Purity: 99.05
• Solubility: DMSO : 125 mg/mL (ultrasonic;warming;heat to 60°C)
• Smiles: OC1=CC=C(C(C2=CNC3=C2C=CC=C3)C4=CNC5=C4C=CC=C5)C=C1
• Molecular Weight: 338.40
• References & Citations: [1]Hedrick E, et al. Nuclear Receptor 4A1 (NR4A1) as a Drug Target for Renal Cell Adenocarcinoma. PLoS One. 2015 Jun 2;10(6):e0128308.|[2]Hedrick E, et al. NR4A1 Antagonists Inhibit β1-Integrin-Dependent Breast Cancer Cell Migration. Mol Cell Biol. 2016 Apr 15;36(9):1383-94.
• Shipping Conditions: Room Temperature
• Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
• Clinical Information: No Development Reported