DIM-C-pPhOH

• Description :

  DIM-C-pPhOH is a nuclear receptor 4A1 (NR4A1) antagonist. DIM-C-pPhOH inhibits cancer cell growth and mTOR signaling, induce apoptosis and cellular stress. DIM-C-pPhOH reduces cell proliferation with IC50 values of 13.6 μM and 13.0 μM for ACHN cells and 786-O cells, respectively[1].

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  Apoptosis; Nuclear Hormone Receptor 4A/NR4A

• Type :

  Reference compound

• Related Pathways :

  Apoptosis; Vitamin D Related/Nuclear Receptor

• Applications :

  Neuroscience-Neurodegeneration

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/dim-c-pphoh.html

• Purity :

  99.05

• Solubility :

  DMSO : 125 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles :

  OC1=CC=C(C(C2=CNC3=C2C=CC=C3)C4=CNC5=C4C=CC=C5)C=C1

• Molecular Formula :

  C23H18N2O

• Molecular Weight :

  338.40

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Hedrick E, et al. Nuclear Receptor 4A1 (NR4A1) as a Drug Target for Renal Cell Adenocarcinoma. PLoS One. 2015 Jun 2;10 (6) :e0128308.|[2]Hedrick E, et al. NR4A1 Antagonists Inhibit β1-Integrin-Dependent Breast Cancer Cell Migration. Mol Cell Biol. 2016 Apr 15;36 (9) :1383-94.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  Nur77/NR4A1

• CAS Number :

  [151358-47-3]