CL2 Linker

• Description :

  CL2 Linker is a cleavableADC linker. CL2-SN-38 and CL2A-SN-38 are equivalent in agent substitution (~6), cell binding (Kd ~1.2 nM), cytotoxicity (IC50 ~2.2 nM), and serum stability in vitro (t1/2 ~20 hours) [1][2].

• UNSPSC :

  12352203

• Hazard Statement :

  H302-H315-H319-H335

• Target :

  ADC Linker

• Type :

  ADC Related

• Related Pathways :

  Antibody-drug Conjugate/ADC Related

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/cl2-linker.html

• Solubility :

  10 mM in DMSO

• Smiles :

  OCC(COC(N(C)CCN(C)C(OCC(C=C1)=CC=C1NC([C@H](CCCCNC(OC(C)(C)C)=O)NC([C@@H](NC(CCOCCOCCOCCOCCOCCOCCOCCOCCN2C=C(CNC(CCCCCN3C(C=CC3=O)=O)=O)N=N2)=O)CC4=CC=CC=C4)=O)=O)=O)=O)=O

• Molecular Formula :

  C68H103N11O22

• Molecular Weight :

  1426.61

• Precautions :

  P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

• References & Citations :

  [1]Moon SJ, et al. Antibody conjugates of 7-ethyl-10-hydroxycamptothecin (SN-38) for targeted cancer chemotherapy. J Med Chem. 2008 Nov 13;51 (21) :6916-26.|[2]Cardillo TM, et al. Humanized anti-Trop-2 IgG-SN-38 conjugate for effective treatment of diverse epithelial cancers: preclinical studies in human cancer xenograft models and monkeys. Clin Cancer Res. 2011 May 15;17 (10) :3157-69.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  ADC Related

• Clinical Information :

  No Development Reported

• Isoform :

  Acid Cleavable Linker; Cleavable Linker

• CAS Number :

  [2270986-66-6]