(±) 8 (9) -EET

• Description:

  (±) 8 (9) -EET is one of the main metabolites produced by the metabolism of arachidonic acid (HY-109590) through the cytochrome P450 epoxide pathway. (±) 8 (9) -EET is an effective substrate for COX-1 and COX-2. (±) 8 (9) -EET activates PPARα in HEK293 cells and inhibits the activity of NF-κB induced by IL-1β in a PPARα-dependent and -independent manner. The (8S,9R) -isomer of (±) 8 (9) -EET ([ (8S,9R) -EET]) causes vasoconstriction, thereby reducing renal plasma flow and glomerular filtration rate[1][2][3][4][5].

• UNSPSC:

  12352211

• Target:

  COX; Drug Metabolite; NF-κB; PPAR

• Related Pathways:

  Cell Cycle/DNA Damage; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB; Vitamin D Related/Nuclear Receptor

• Field of Research:

  Metabolic Disease

• Smiles:

  CCCCC/C=C\C/C=C\CC1OC1C/C=C\CCCC(O)=O

• Molecular Formula:

  C20H32O3

• Molecular Weight:

  320.47

• References & Citations:

  [1]Katoh T, et al. Glomerular stereospecific synthesis and hemodynamic actions of 8,9-epoxyeicosatrienoic acid in rat kidney. Am J Physiol. 1991 Oct;261 (4 Pt 2) :F578-86.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Natural Products

• Clinical Information:

  No Development Reported

• CAS Number:

  [184488-44-6]