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11R (12S) -EET

CAT: 0804-HY-N12962A-01Size: 25 µgDry Ice: NoHazardous: No
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CAT#:0804-HY-N12962A-01Size:25 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
11R (12S) -EET is a cis-epoxytrienoic acid (EETs) derivative that is metabolized by cytoplasmic cyclooxygenases. Studies have shown that 14 (R), 15 (S) -, 11 (S),12 (R) -, and 8 (S),9 (R) -EETs are metabolized at significantly higher rates than their enantiomers. Enzyme-catalyzed hydration revealed that water addition was non-regioselective for the 11,12-EET enantiomers, whereas water addition occurred primarily at the C9 position for both enantiomers of 8,9-EET. These results suggest that the metabolic properties of 11R (12S) -EET and other EET enantiomers in enzyme-catalyzed processes are significantly affected by their stereostructures[1].
CAS Number
123931-38-4
UNSPSC
12352005
Target
Others
Type
Natural Products
Related Pathways
Others
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/11r-12s-eet.html
Smiles
OC(CCC/C=C\C/C=C\C[C@@H]1[C@@H](O1)C/C=C\CCCCC)=O
Molecular Formula
C20H32O3
Molecular Weight
320.47
References & Citations
[1]Zeldin DC, et al. Metabolism of epoxyeicosatrienoic acids by cytosolic epoxide hydrolase: substrate structural determinants of asymmetric catalysis. Arch Biochem Biophys. 1995 Jan 10;316 (1) :443-51.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported

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