11R(12S)-EET

11R(12S)-EET

• CAS Number: 123931-38-4
• UNSPSC Description: 11R(12S)-EET is a cis-epoxytrienoic acid (EETs) derivative that is metabolized by cytoplasmic cyclooxygenases. Studies have shown that 14(R), 15(S)-, 11(S),12(R)-, and 8(S),9(R)-EETs are metabolized at significantly higher rates than their enantiomers. Enzyme-catalyzed hydration revealed that water addition was non-regioselective for the 11,12-EET enantiomers, whereas water addition occurred primarily at the C9 position for both enantiomers of 8,9-EET. These results suggest that the metabolic properties of 11R(12S)-EET and other EET enantiomers in enzyme-catalyzed processes are significantly affected by their stereostructures[1].
• Target Antigen: Others
• Type: Natural Products
• Related Pathways: Others
• Field of Research: Others
• Assay Protocol: https://www.medchemexpress.com/11r-12s-eet.html
• Smiles: OC(CCC/C=C\C/C=C\C[C@@H]1[C@@H](O1)C/C=C\CCCCC)=O
• Molecular Weight: 320.47
• References & Citations: [1]Zeldin DC, et al. Metabolism of epoxyeicosatrienoic acids by cytosolic epoxide hydrolase: substrate structural determinants of asymmetric catalysis. Arch Biochem Biophys. 1995 Jan 10;316(1):443-51.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported