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AR ligand-48

CAT: 0804-HY-179442Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-179442Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
AR ligand-48 is an AR (Androgen Receptor) inhibitor and a ligand for the target protein for PROTAC (AR). AR ligand-48 can be used to synthesize PROTAC AR Degrader-12.
CAS Number
1318208-88-6
UNSPSC
12352005
Target
Androgen Receptor; Ligands for Target Protein for PROTAC
Related Pathways
PROTAC; Vitamin D Related/Nuclear Receptor
Field of Research
Cancer
Smiles
COC(C1=CC(OCC(C)C)=C(C=C1)NC(C2=CC(OCC(C)C)=C(C=C2)[N+]([O-])=O)=O)=O
Molecular Formula
C23H28N2O7
Molecular Weight
444.48
References & Citations
[1]Wu Y, et al. Kill Two Birds with One Stone: An Efficient and Potent AR CBS-Targeted Degrader Reverses Breast Cancer Resistance via Concurrent AR Degradation and ERα Transcriptional Suppression. J Med Chem. 2025 Nov 27;68 (22) :24136-24167.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported