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NSD2/H3K36me2 modulator-1

CAT: 0804-HY-179427Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-179427Size:1 Each
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Description
NSD2/H3K36me2 modulator-1 is an orally active NSD2/H3K36me2 modulator. NSD2/H3K36me2 modulator-1 competitively binds to the SAM pocket of NSD2, potently inhibits NSD2 expression and suppresses H3K36me2 methylation. NSD2/H3K36me2 modulator-1 reverses epithelial-mesenchymal transition (EMT), inhibits cell migration, and induces G0/G1 phase arrest and apoptosis. NSD2/H3K36me2 modulator-1 induces decreased Mitochondrial membrane potential (MMP) and subsequent Reactive oxygen species (ROS) generation. NSD2/H3K36me2 modulator-1 can be used to research the NSD2-targeting epigenetic anticancer strategies for hepatocellular carcinoma (HCC) [1].
UNSPSC
12352005
Target
Apoptosis; Histone Methyltransferase; Reactive Oxygen Species (ROS)
Related Pathways
Apoptosis; Epigenetics; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Field of Research
Cancer
Smiles
ClC1=CC(N(CC(N[C@@H]2C(C)(C)[C@@](CC[C@]3(C)[C@@]4([H])C[C@@H](O)[C@@]5([H])[C@@]3(C)CC[C@]5([H])[C@@]6(C)CCCC(C)(C)O6)(C)[C@]4(C)CC2)=O)C(C7=O)=O)=C7C=C1
Molecular Formula
C41H59ClN2O5
Molecular Weight
695.37
References & Citations
[1]Lv L, et al. Synthesis of amide-linked panaxadiol-indolinedione derivatives: A novel NSD2/H3K36me2 epigenetic modulator with significant antitumor efficacy. Eur J Med Chem. 2026 Jan 15;302 (Pt 1) :118275.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
NSD2/MMSET/WHSC1

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Alternative Products

CatalogName
GTR19273788-01NSD2/H3K36me2 modulator-1
GTR19185884-01NSD2-IN-1
T204951-01NSD2-PWWP1-IN-1
T209955-01NSD2-PWWP1 ligand 1
ARG7387NSD2 Knockout THP-1 Polyclonal Cells
495602WHSC1 (Histone-lysine N-methyltransferase NSD2, Wolf-Hirschhorn Syndrome Candidate 1)
MBS6012708-01WHSC1 (Wolf-Hirschhorn Syndrome Candidate 1 Protein, Histone-lysine N-methyltransferase NSD2, KIAA1090, Multiple Myeloma SET Domain-containing Protein, MMSET, Nuclear SET Domain-containing Protein 2, NSD2, Protein Trithorax-5, TRX5, WHS, REIIBP)
043873WHSC1, CT (WHSC1, KIAA1090, MMSET, NSD2, TRX5, Probable histone-lysine N-methyltransferase NSD2, Multiple myeloma SET domain-containing protein, Nuclear SET domain-containing protein 2, Protein trithorax-5, Wolf-Hirschhorn syndrome candidate 1 protein) discontinued
043873-APWHSC1, CT (WHSC1, KIAA1090, MMSET, NSD2, TRX5, Probable histone-lysine N-methyltransferase NSD2, Multiple myeloma SET domain-containing protein, Nuclear SET domain-containing protein 2, Protein trithorax-5, Wolf-Hirschhorn syndrome candidate 1 protein) (AP) discontinued
043873-FITCWHSC1, CT (WHSC1, KIAA1090, MMSET, NSD2, TRX5, Probable histone-lysine N-methyltransferase NSD2, Multiple myeloma SET domain-containing protein, Nuclear SET domain-containing protein 2, Protein trithorax-5, Wolf-Hirschhorn syndrome candidate 1 protein) (FITC) discontinued

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