CypD-IN-7

• Description :

  CypD-IN-7 is a potent cyclophilin D (CypD/PPIF) inhibitor that inhibits CypD PPIase activity (Ki = 2.4 nM) and provides protection against mitochondrial permeability transition pore (MPTP) opening. CypD-IN-7 can be used for pancreatitis research[1].

• UNSPSC :

  12352005

• Target :

  Cyclophilin

• Related Pathways :

  Immunology/Inflammation

• Field of Research :

  Inflammation/Immunology

• Smiles :

  FC1=CC=C(C(N2CCCN2C([C@@H](NC(NCC3=CC4=C(N[C@H]5[C@H](O)CO[C@@H]4C5)C=C3)=O)C6=CC=C(C7=CC=C(CN8CCOCC8)C=C7)C=C6)=O)=C1)Cl

• Molecular Formula :

  C41H44ClFN6O5

• Molecular Weight :

  755.28

• References & Citations :

  [1]Awais M, et al. Potent Preorganized Pyrazolidine Cyclophilin D Inhibitors Prevent Mitochondrial and Organ Injury in a Mouse Pancreatitis Disease Model. J Med Chem. 2025;68 (22) :23910-23924. doi:10.1021/acs.jmedchem.5c01146

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  Cyclophilin D