CypD-IN-6

• Description :

  CypD-IN-6 is a potent cyclophilin D (CypD/PPIF) inhibitor that inhibits CypD PPIase activity (Ki = 32 nM) and binds to CypD (Kd = 60 nM) . CypD-IN-6 can be used for mitochondrial permeability transition pore (MPTP) related disease research such as ischemia-reperfusion injury and acute pancreatitis1.

• UNSPSC :

  12352005

• Target :

  Cyclophilin

• Related Pathways :

  Immunology/Inflammation

• Field of Research :

  Inflammation/Immunology

• Smiles :

  NC1=CC=C(C=C1)CNC(NCC(N2N(CCC2)C3=CC=CC=C3Br)=O)=O

• Molecular Formula :

  C19H22BrN5O2

• Molecular Weight :

  432.31

• References & Citations :

  [1]Awais M, et al. Potent Preorganized Pyrazolidine Cyclophilin D Inhibitors Prevent Mitochondrial and Organ Injury in a Mouse Pancreatitis Disease Model. J Med Chem. 2025;68 (22) :23910-23924. doi:10.1021/acs.jmedchem.5c01146

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  Cyclophilin D