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CXCR2-IN-3

CAT: 0804-HY-179387Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-179387Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CXCR2-IN-3 is a CXCR2 inhibitor with an IC50 of 11.37 μM. CXCR2-IN-3 mediates CXCR2-Ca2+ signalling inhibition halted autophagic flux, subsequently facilitating ROS-mediated apoptotic cell death. CXCR2-IN-3 suppresses the CXCR2-NLRP3 canonical pathway, suppressing pre-tumorigenic markers. CXCR2-IN-3 causes autophagy-dependent cell death in polyploid giant cancer cells (PGCCs) . CXCR2-IN-3 can be used for the research of oral squamous cell carcinoma (OSCC) [1].
UNSPSC
12352005
Target
Apoptosis; Autophagy; CXCR; NOD-like Receptor (NLR) ; Reactive Oxygen Species (ROS)
Related Pathways
Apoptosis; Autophagy; GPCR/G Protein; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Field of Research
Cancer
Smiles
O=C1C(C(NC2=CC3=C(NC=C3)C=C2)=C1NC4=CC=C(C(C(F)(F)F)(O)C(F)(F)F)C=C4)=O
Molecular Formula
C21H13F6N3O3
Molecular Weight
469.34
References & Citations
[1]Jadhav GS, et al. Discovery of a fluorinated squaramide as a potential CXCR2- autophagy signalling modulator in chemo-resistant oral squamous cell carcinoma and polyploid giant cancer cells. Eur J Med Chem. 2026;302 (Pt 1) :118289.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CXCR2; NLRP3

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