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CXCR2 antagonist 4

CAT: 0804-HY-144780Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-144780Size:1 Each
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Description
CXCR2 antagonist 4 (compound 7) is a potent CXCR2 antagonist with an IC50 value of 0.13 μM. CXCR2 antagonist 4 can inhibit CXCL8-induced cytosolic calcium increase (IC50 = 27 μM) . CXCR2 antagonist 4 can be used for researching anticancer[1].
UNSPSC
12352005
Target
CXCR
Type
Reference compound
Related Pathways
GPCR/G Protein; Immunology/Inflammation
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cxcr2-antagonist-4.html
Solubility
10 mM in DMSO
Smiles
OC[C@@H](C)NC1=C2SC=NC2=NC(SCC3=CC=CC(F)=C3F)=N1
Molecular Formula
C15H14F2N4OS2
Molecular Weight
368.42
References & Citations
[1]Van Hoof M, et al. Identification of novel chemotypes as CXCR2 antagonists via a scaffold hopping approach from a thiazolo[4,5-d]pyrimidine. Eur J Med Chem. 2022;235:114268.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CXCR2

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