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CXCR2-IN-2

CAT: 0804-HY-120878-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-120878-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CXCR2-IN-2 is a selective, brain penetrant, and orally bioavailable CXCR2 antagonist (IC50=5.2 nM/1 nM in β-arrestin assay/CXCR2 Tango assay, respectively) . CXCR2-IN-2 displays ~730-fold selectivity over CXCR1 and >1900-fold selectivity over all other chemokine receptors. CXCR2-IN-2 inhibits human whole blood Gro-α induced CD11b expression with an IC50 of 0.04 μM[1].
CAS Number
1838123-21-9
UNSPSC
12352005
Target
CXCR
Type
Reference compound
Related Pathways
GPCR/G Protein; Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/cxcr2-in-2.html
Purity
99.52
Solubility
DMSO : 240 mg/mL (ultrasonic)
Smiles
O=C(N[C@H]1C(C)=CCC1)NC2=CC=C(Cl)C(S(=O)([C@]3(C)COCC3)=O)=C2O
Molecular Formula
C18H23ClN2O5S
Molecular Weight
414.90
References & Citations
[1]Lu H, et al. Discovery of Novel 1-Cyclopentenyl-3-phenylureas as Selective, Brain Penetrant, and Orally Bioavailable CXCR2 Antagonists. J Med Chem. 2018;61 (6) :2518-2532.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CXCR1; CXCR2

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