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Ferroptosis/apoptosis inducer-3

CAT: 0804-HY-179016Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-179016Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Ferroptosis/apoptosis inducer-3 (Compound 34) is a Ferroptosis and Apoptosis inducer. Ferroptosis/apoptosis inducer-3 induces both Ferroptosis and Apoptosis by causing G2/M phase cell cycle arrest, disrupting mitochondrial membrane potentials, promoting lipid peroxidation, and increasing the levels of Ca2+ and Fe2+ through the activation of calcium/calmodulin signaling. Ferraplasm/apoptosis inducer-3 shows anticancer effects against cervical cancer, adenocarcinoma, breast cancer, colon cancer, and colorectal carcinoma[1].
UNSPSC
12352005
Target
Apoptosis; Calcium Channel; Ferroptosis; Mitochondrial Metabolism
Related Pathways
Apoptosis; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling
Field of Research
Cancer
Smiles
COC1=CC(C2=NC=CC3=NC(C4=CNC5=C4C(F)=CC=C5)=NN23)=CC(OC)=C1OC
Molecular Formula
C22H18FN5O3
Molecular Weight
419.41
References & Citations
[1]Chen L, et al. Dual Induction of Ferroptosis and Apoptosis by Triazolopyrimidinyl Derivatives: Design, Synthesis, and Biological Evaluation for Their Anticancer Efficacy via Calcium/Calmodulin Signaling and Mitochondrial Impairment. J Med Chem. 2025 Nov 13;68 (21) :23024-23049.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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