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Ferroptosis inducer-8

CAT: 0804-HY-174345Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-174345Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Ferroptosis inducer-8 is a ferroptosis inducer with high selectivity for other cell death mechanism. Ferroptosis inducer-8 induces ferroptosis by affecting ACSL4, GPX4, and FTH1, thereby disrupting intracellular iron homeostasis and the GSH/GPX4 antioxidant defense system, ultimately leading to the accumulation of lipid peroxidation. Ferroptosis inducer-8 also induces ROS production. Ferroptosis inducer-8 inhibits tumor growth and can be used for research of triple-negative breast cancer (TNBC) [1].
CAS Number
3097194-74-3
UNSPSC
12352101
Target
Ferroptosis; Glutathione Peroxidase; Reactive Oxygen Species (ROS)
Related Pathways
Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
O=C(OC)C1=CO[C@@H](OC)[C@]2([H])C(CN(C3=CC(OC)=C(Cl)C(OC)=C3)C(CCl)=O)=CC[C@@]21[H]
Molecular Formula
C22H25Cl2NO7
Molecular Weight
486.34
References & Citations
[1]Yu JW, et al. Discovery of novel genipin derivatives as highly selective ferroptosis inducers for the treatment of triple-negative breast cancer. Eur J Med Chem. 2025 Oct 5;295:117823.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
GPX4

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