Ferroptosis inducer-8

• Description:

  Ferroptosis inducer-8 is a ferroptosis inducer with high selectivity for other cell death mechanism. Ferroptosis inducer-8 induces ferroptosis by affecting ACSL4, GPX4, and FTH1, thereby disrupting intracellular iron homeostasis and the GSH/GPX4 antioxidant defense system, ultimately leading to the accumulation of lipid peroxidation. Ferroptosis inducer-8 also induces ROS production. Ferroptosis inducer-8 inhibits tumor growth and can be used for research of triple-negative breast cancer (TNBC) [1].

• UNSPSC:

  12352101

• Target:

  Ferroptosis; Glutathione Peroxidase; Reactive Oxygen Species (ROS)

• Related Pathways:

  Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Smiles:

  O=C(OC)C1=CO[C@@H](OC)[C@]2([H])C(CN(C3=CC(OC)=C(Cl)C(OC)=C3)C(CCl)=O)=CC[C@@]21[H]

• Molecular Formula:

  C22H25Cl2NO7

• Molecular Weight:

  486.34

• References & Citations:

  [1]Yu JW, et al. Discovery of novel genipin derivatives as highly selective ferroptosis inducers for the treatment of triple-negative breast cancer. Eur J Med Chem. 2025 Oct 5;295:117823.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  GPX4

• CAS Number:

  [3097194-74-3]