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Ferroptosis inducer-8

CAT: 0931-T212017-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T212017-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
3097194-74-3
Target
Glutathione Peroxidase, ROS, Ferroptosis
Related Pathways
Metabolism, Immunology/Inflammation, Apoptosis
Bioactivity
Ferroptosisinducer-8 is a ferroptosis (iron-dependent cell death) inducer with high selectivity against other cell death pathways. It induces ferroptosis by affecting ACSL4, GPX4, and FTH1, disrupting intracellular iron homeostasis and the GSH/GPX4 antioxidant defense system, leading to the accumulation of lipid peroxides. Ferroptosisinducer-8 also stimulates ROS production and can inhibit tumor growth, making it useful for research in triple-negative breast cancer (TNBC) .
Smiles
C(N(C(CCl)=O)C1=CC(OC)=C(Cl)C(OC)=C1)C=2[C@@]3([C@@](C(C(OC)=O)=CO[C@H]3OC)(CC2)[H])[H]
Molecular Formula
C22H25Cl2NO7
Molecular Weight
486.34
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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