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Ferroptosis inducer-9

CAT: 0804-HY-175698Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-175698Size:1 Each
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Description
Ferroptosis inducer-9 is a ferroptosis inducer and colchicine site tubulin polymerization inhibitor. Ferroptosis inducer-9 inhibits MCF-7 cell growth with an IC50 of 14 nM and inhibits [3H]colchicine binding. Ferroptosis inducer-9 reduces expression of GPX4 and FTH, increases COX2 and ACSL4, lowers GSH, NADP+, and NADPH levels, increases LPO, MDA, and Fe (II) levels, and decreases SOD concentrations. Ferroptosis inducer-9 demonstrates significant anti-tumor efficacy in HCT116 CRC xenograft model. Ferroptosis inducer-9 can be used for the study of triple negative breast cancer (TNBC) and colorectal cancer (CRC) [1].
UNSPSC
12352005
Target
COX; Ferroptosis; Glutathione Peroxidase; Microtubule/Tubulin
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Cytoskeleton; Immunology/Inflammation; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
O=C(C1=CN(C2=NC=CS2)C=C1C3=CC=CO3)C4=CC(OC)=C(OC)C(OC)=C4
Molecular Formula
C21H18N2O5S
Molecular Weight
410.44
References & Citations
[1]Masci D, et al. Ferroptosis Induction by a New Pyrrole Derivative in Triple Negative Breast Cancer and Colorectal Cancer. J Med Chem. 2025 Aug 28;68 (16) :17840-17858.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
GPX4

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