Ferroptosis inducer-9

• Description:

  Ferroptosis inducer-9 is a ferroptosis inducer and colchicine site tubulin polymerization inhibitor. Ferroptosis inducer-9 inhibits MCF-7 cell growth with an IC50 of 14 nM and inhibits [3H]colchicine binding. Ferroptosis inducer-9 reduces expression of GPX4 and FTH, increases COX2 and ACSL4, lowers GSH, NADP+, and NADPH levels, increases LPO, MDA, and Fe (II) levels, and decreases SOD concentrations. Ferroptosis inducer-9 demonstrates significant anti-tumor efficacy in HCT116 CRC xenograft model. Ferroptosis inducer-9 can be used for the study of triple negative breast cancer (TNBC) and colorectal cancer (CRC) [1].

• UNSPSC:

  12352005

• Target:

  COX; Ferroptosis; Glutathione Peroxidase; Microtubule/Tubulin

• Related Pathways:

  Apoptosis; Cell Cycle/DNA Damage; Cytoskeleton; Immunology/Inflammation; Metabolic Enzyme/Protease

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Smiles:

  O=C(C1=CN(C2=NC=CS2)C=C1C3=CC=CO3)C4=CC(OC)=C(OC)C(OC)=C4

• Molecular Formula:

  C21H18N2O5S

• Molecular Weight:

  410.44

• References & Citations:

  [1]Masci D, et al. Ferroptosis Induction by a New Pyrrole Derivative in Triple Negative Breast Cancer and Colorectal Cancer. J Med Chem. 2025 Aug 28;68 (16) :17840-17858.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  GPX4