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CDC20/HSP90-IN-1

CAT: 0804-HY-179012Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-179012Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CDC20/HSP90-IN-1 (Compound 2b) is a Cdc20/Hsp90 inhibitor with a Kd of 16.2 μM for Cdc20 and a Kd of 0.241 μM for Hsp90α. CDC20/HSP90-IN-1 exerts potent antitumor activity through reducing p53-mediated Cdc20, upregulating Bim, downregulating Cyclin B1 expression, and disturbing B-Raf and AKT pathways via destroying Hsp90 chaperone function. CDC20/HSP90-IN-1 overcomes Vemurafenib -induced resistant melanoma[1].
Target
Akt; APC; CDK; HSP; Raf
Related Pathways
Cell Cycle/DNA Damage; MAPK/ERK Pathway; Metabolic Enzyme/Protease; PI3K/Akt/mTOR
Field of Research
Cancer
Smiles
O=C(NC(C(Cl)(Cl)Cl)NC1=NC=CC=N1)OCCOCCOCC2=CN(N=N2)CCC#CC3=CN(C4=NC(N)=NC(Cl)=C43)CC5=C(C(OC)=C(C=N5)C)C
Molecular Formula
C33H36Cl4N12O5
Molecular Weight
822.53
References & Citations
[1]Chen Q, et al. Discovery of Cdc20/Hsp90 Dual-Target Inhibitors with Potent Antitumor Activity for Therapy of Acquired Resistant Melanoma. J Med Chem. 2025 Nov 13;68 (21) :22428-22454.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
B-Raf; CDK1; HSP90

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