HSP90/mTOR-IN-1

HSP90/mTOR-IN-1

• CAS Number: 3033543-67-5
• UNSPSC Description: HSP90/mTOR-IN-1 is a potent and orally active Hsp90 and mTOR inhibitor with IC50 values of 69 nM and 29 nM, respectively. HSP90/mTOR-IN-1 suppresses the proliferation of SW780 cells through the over-activation of the PI3K/AKT/mTOR pathway. HSP90/mTOR-IN-1 induces apoptosis and autophagy via selective Hsp90 and mTOR inhibition. HSP90/mTOR-IN-1 also has considerable in vivo anti-tumor activity. HSP90/mTOR-IN-1 can be used for researching bladder cancer[1].
• Target Antigen: Apoptosis; Autophagy; HSP; mTOR
• Type: Reference compound
• Related Pathways: Apoptosis;Autophagy;Cell Cycle/DNA Damage;Metabolic Enzyme/Protease;PI3K/Akt/mTOR
• Applications: Cancer-Kinase/protease
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/hsp90-mtor-in-1.html
• Solubility: 10 mM in DMSO
• Smiles: ClC1=CC(NC(NC2=CC=C(C=C2)C3=NC(N4CCOCC4)=C5C6=C(SC5=N3)CN(CC6)C(C7=CC(C(C)C)=C(C=C7O)O)=O)=O)=CC=C1F
• Molecular Weight: 717.21
• References & Citations: [1]Pan Z, et al. Design, synthesis, and biological evaluation of novel dual inhibitors of heat shock protein 90/mammalian target of rapamycin (Hsp90/mTOR) against bladder cancer cells. Eur J Med Chem. 2022 Aug 13;242:114674.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported