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ONO-7927846

CAT: 0804-HY-179005Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-179005Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ONO-7927846 is a potent, orally active, selective and CNS penetrant dual TREK-1/TREK-2 inhibitor (TREK-1 IC50= 0.11 μM, TREK-2 IC50= 0.29 μM). ONO-7927846 displays robust efficacy in an MK-801 challenge rat novel object recognition (NOR) paradigm. ONO-7927846 can be used for research on neurological and cognitive disorders[1].
CAS Number
2640753-27-9
Product Name Alternative
VU6024391
UNSPSC
12352005
Target
Potassium Channel
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Smiles
CC1=C(N=CC(C#CC2=CC=C(C=C2)F)=C1)NC(C3=C(C=NN3[C@H]4[C@@H](CN(CC4)C(C)=O)F)Cl)=O
Molecular Formula
C25H22ClF2N5O2
Molecular Weight
497.92
References & Citations
[1]Tanaka M, et al. Optimization of Selective and CNS Penetrant Alkyne-Based TREK Inhibitors: The Discovery and Characterization of ONO-9517601 (VU6022856) and ONO-7927846 (VU6024391) . J Med Chem. 2025;68 (21) :23554-23572.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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