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TRPA1 agonist-3

CAT: 0804-HY-175980Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-175980Size:1 Each
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Description
TRPA1 agonist-3 is a selective and orally active TRPA1 agonist, with EC50 values of 50.05 μM and 314.04 μM for human and mouse TRPA1, respectively. TRPA1 agonist-3 does not activate hTRPV1, mTRPV2, hTRPV3, hTRPV4, hTRPC6, or hTRPM8 channels. TRPA1 agonist-3 alleviates inflammatory pain in mice through a channel desensitization mechanism[1].
CAS Number
3083086-77-2
UNSPSC
12352005
Target
TRP Channel
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Smiles
COCCCNC1=NC(C2=CC=C(C=C2)C)=CS1
Molecular Formula
C14H18N2OS
Molecular Weight
262.37
References & Citations
[1]Sun C, et al. Identification of a Nonelectrophilic and Selective TRPA1 Agonist for Alleviation of Inflammatory Pain through Channel Desensitization. ACS Chem Neurosci. 2025 Sep 3;16 (17) :3257-3266.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
TRPA1

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