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PI3KC2γ-IN-1

CAT: 0804-HY-178371Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-178371Size:1 Each
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Description
PI3KC2γ-IN-1 (Compound 23) is an orally active and selective PI3KC2γ inhibitor (IC50 = 4 nM) . PI3KC2γ-IN-1 downregulats the Akt2-glycogen synthase (GS) signaling pathway, ultimately inhibiting the conversion of glucose to glycogen and reduces excessive glycogen accumulation in the liver. PI3KC2γ-IN-1 can significantly inhibit insulin-induced PI (3,4) P2 accumulation in both primary hepatocytes and HepG2 liver cancer cells. PI3KC2γ-IN-1 can be used for the study of glycogen storage diseases (GSDs) [1].
UNSPSC
12352005
Target
PI3K
Related Pathways
PI3K/Akt/mTOR
Field of Research
Metabolic Disease
Smiles
O=C(NC1=CC=CN=C1)NC2=CC=C(OC(C3=CC=C4N=C(N)SC4=C3)=N5)C5=C2
Molecular Formula
C20H14N6O2S
Molecular Weight
402.43
References & Citations
[1]Zhong Y, et al. Discovery of novel PI3KC2γ inhibitors with high potency, selectivity, and favorable pharmacokinetics for glycogen metabolism regulation. Eur J Med Chem. 2025 Jul 5;291:117621.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PI3KC2γ

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