PI3Kβ-IN-1

CAT: 0804-HY-145338Size: 1 EachDry Ice: NoHazardous: No

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CAT#:0804-HY-145338Size:1 Each

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Description

PI3Kβ-IN-1 (compound (P) -14) is a selective and orally active PI3Kβ inhibitor, with an IC50 of 2 nM[1].

CAS Number

2215098-77-2

UNSPSC

12352005

Target

PI3K

Type

Reference compound

Related Pathways

PI3K/Akt/mTOR

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/pi3kβ-in-1.html

Solubility

10 mM in DMSO

Smiles

CC([N@](C1=C2)[C@]3=CC=NC4=C(F)C=CC(F)=C34)=NC1=C(C5=NN=CN5)C=C2C6=CC=NC(C#N)=C6

Molecular Formula

C25H14F2N8

Molecular Weight

464.43

References & Citations

[1]Perreault S, et al. Discovery of an Atropisomeric PI3Kβ Selective Inhibitor through Optimization of the Hinge Binding Motif. ACS Med Chem Lett. 2020 Apr 13;11 (6) :1236-1243.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Related Products

Catalog	Name
HY-156091	PI3Kα/HDAC6-IN-1
HY-151635	PI3K/VEGFR2-IN-1
HY-U00326	PI3Kα/mTOR-IN-1
HY-128582	PI3K/HDAC-IN-1
HY-144806-01	PI3K/AKT-IN-1
HY-174396	PI3Kδ/HDAC6-IN-1
HY-172130	PI3Kδ/BET-IN-1
HY-173007	ALK/PI3K/AKT-IN-1
HY-112602	PI3K/mTOR Inhibitor-1
HY-176421	PROTAC PI3K/110β degrader-1

Alternative Products

Catalog	Name
T87158-01	PI3Kα-IN-1
T12462-01	PI3Kδ-IN-1
T1826-01	PI3K-IN-1
GTR19185153-01	PI3Kδ/γ-IN-1
T62948-01	PI3Kβ-IN-1
M33055-01	PARP, PI3K-IN-1
GTR19205047-01	PI3Kα/mTOR-IN-1
GTR19239085-01	EGFR/PI3Kα-IN-1
GTR19231438-01	PI3K/VEGFR2-IN-1
C03280-25mg	PI3K/AKT-IN-1

PI3Kβ-IN-1

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