SDH-IN-32

• Description :

  SDH-IN-32 is a succinate dehydrogenase (SDH) inhibitor with an IC50 of 2.74 μM. SDH-IN-32 exhibits excellent antifungal activity. SDH-IN-32 can destroy the cell membrane structure and increase the permeability of the cell membrane. SDH-IN-32 can decrease the mitochondrial membrane potential (MMP), thereby inducing cell apoptosis and inhibiting the normal growth of mycelia. SDH-IN-32 can be used for the research of infection[1].

• UNSPSC :

  12352101

• Target :

  Apoptosis; Fungal; MMP

• Related Pathways :

  Anti-infection; Apoptosis; Metabolic Enzyme/Protease

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Infection

• Smiles :

  O=C(NNC1=CC=C(F)C=C1)COC2=C(C)CC(C)(C)CC2=O

• Molecular Formula :

  C17H21FN2O3

• Molecular Weight :

  320.36

• References & Citations :

  [1]Chen H, et al. Discovery of Novel Isophorone Derivatives as Potential Succinate Dehydrogenase Inhibitors: Design, Synthesis, Antifungal Evaluation, and Action Mechanism. J Agric Food Chem. 2025 Sep 24;73 (38) :24416-24426.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported