CDK9-IN-42

• Description:

  CDK9-IN-42 is a potent and selective CDK9 inhibitor with an IC50of 3.8 nM. CDK9-IN-42 can inhibit the growth of cancer cells and induce apoptosis by downregulating Myc-1 and c-Myc. CDK9-IN-42 can be used for the research of cancer, such as breast and lungcancer[1].

• UNSPSC:

  12352005

• Target:

  Apoptosis; Caspase; CDK; c-Myc; PARP

• Related Pathways:

  Apoptosis; Cell Cycle/DNA Damage; Epigenetics

• Field of Research:

  Cancer

• Smiles:

  FC1=CC(OC)=C(C2=NC=NC(NC3=CC(CS(C)(=NC(C4=CN=CS4)=O)=O)=CC=C3)=N2)C=C1

• Molecular Formula:

  C22H19FN6O3S2

• Molecular Weight:

  498.55

• References & Citations:

  [1]Liu Y, et al. Design, Synthesis, and Biological Evaluation of Sulfonamide Derivatives as Potent CDK9 Inhibitors. ACS Med Chem Lett. 2025 Aug 26;16 (9) :1860-1867.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  Caspase 3; CDK9