TDI-014925

• Description:

  TDI-014925 (Compound 58) is a SARS-CoV-2 methyltransferase nonstructural protein 14 (NSP14) inhibitor with an IC50 of 0.2 nM. TDI-014925 has an antiviral activity with significant microsomal stability and no CYP inhibitory activity. TDI-014925 can be used for COVID-19 research[1].

• UNSPSC:

  12352005

• Target:

  SARS-CoV

• Related Pathways:

  Anti-infection

• Field of Research:

  Infection

• Smiles:

  CC1=C(C=C(N1C)C(NCC2=C3C(C=NN3C)=CC=C2F)=O)S(=O)(N4CCC5=NNC=C5C4)=O

• Molecular Formula:

  C22H24FN7O3S

• Molecular Weight:

  485.53

• References & Citations:

  [1]Miller MW, et al. Discovery, Optimization, and Evaluation of Non-Nucleoside SARS-CoV-2 NSP14 Inhibitors. J Med Chem. 2025 Sep 25;68 (18) :19076-19106.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [3052313-53-5]