IRAK4 modulator-2

• Description :

  IRAK4 modulator-2 (Compound 5) is a selective dual Interleukin-1 Receptor Associated Kinase 4 (IRAK4) and IRAK1 inhibitor with IC50 values of 0.005 μM and 0.97 μM, erespectively. IRAK4 modulator-2 blocks IRAK-mediated signaling pathways (e.g., JAK-STAT, NF-κB pathways), reduces the production of pro-inflammatory cytokines (e.g., IL-1, TNF), and exerts anti-inflammatory activity. IRAK4 modulator-2 is promising for research of autoimmune diseases and inflammatory diseases, such as rheumatoid arthritis, psoriasis, inflammatory bowel disease[1].

• CAS Number :

  [1356013-27-8]

• UNSPSC :

  12352005

• Target :

  IRAK; JAK; NF-κB; STAT

• Related Pathways :

  Epigenetics; Immunology/Inflammation; JAK/STAT Signaling; NF-κB; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt

• Field of Research :

  Inflammation/Immunology

• Purity :

  99.86

• Solubility :

  DMSO : 125 mg/mL (ultrasonic)

• Smiles :

  O=C(C1=C2N=CC=CN2N=C1)NC3=CC(Cl)=CC=C3N4CCC(C(C)O)CC4

• Molecular Formula :

  C20H22ClN5O2

• Molecular Weight :

  399.87

• References & Citations :

  [1]Nidhi Arora, et al. Pyrazolo [1, 5a] pyrimidine and thieno [3, 2b] pyrimidine derivatives as irak4 modulators. WO2012007375A1. 2012-01-19.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  IRAK1; IRAK4