Basivarsen linker

• Description:

  Basivarsen linker is a linker used in HY-177452 Zeleciment basivarsen for coupling a TfR1-binding Fab Zeleciment (HY-P990780) and an antisense oligonucleotide. Zeleciment basivarsen is an antibody-oligonucleotide conjugate (AOC) designed to target mutant nuclear myotonic dystrophy protein kinase (DMPK) RNA for RHase H-mediated degradation to correct splicing. It is used for the study of myotonic dystrophy type 1 (DM1) .

• UNSPSC:

  12352005

• Target:

  Antibody-Oligonucleotide Conjugates (AOCs)

• Related Pathways:

  Antibody-drug Conjugate/ADC Related

• Field of Research:

  Others

• Smiles:

  NC(CCOCCOCCOCCOCCNC(OC[C@H]1[C@]2([H])[C@@]1([H])CCC3=C(N(N=N3)CCOCCOCCOCCC(N[C@@H](C(C)C)C(N[C@@H](CCCNC(N)=O)C(NC4=CC=C(C=C4)COC(N)=O)=O)=O)=O)CC2)=O)=O

• Molecular Formula:

  C50H81N11O16

• Molecular Weight:

  1092.24

• References & Citations:

  [1]Weeden, Timothy; Hilderbrand, Scott; Spring, Sean; Shen, Peiyi; Vieira, Benjamin. Methods of preparing protein-oligonucleotide complexes. WO2022051665A1

• Shipping Conditions:

  Room temperature

• Scientific Category:

  ADC Related

• Clinical Information:

  No Development Reported

• CAS Number:

  [2763758-01-4]