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Basivarsen linker

CAT: 0804-HY-177454Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-177454Size:1 Each
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Description
Basivarsen linker is a linker used in HY-177452 Zeleciment basivarsen for coupling a TfR1-binding Fab Zeleciment and an antisense oligonucleotide. Zeleciment basivarsen is an antibody-oligonucleotide conjugate (AOC) designed to target mutant nuclear myotonic dystrophy protein kinase (DMPK) RNA for RHase H-mediated degradation to correct splicing. It is used for the study of myotonic dystrophy type 1 (DM1).
CAS Number
2763758-01-4
UNSPSC
12352005
Target
Antibody-Oligonucleotide Conjugates (AOCs)
Related Pathways
Antibody-drug Conjugate/ADC Related
Field of Research
Others
Smiles
NC(CCOCCOCCOCCOCCNC(OC[C@H]1[C@]2([H])[C@@]1([H])CCC3=C(N(N=N3)CCOCCOCCOCCC(N[C@@H](C(C)C)C(N[C@@H](CCCNC(N)=O)C(NC4=CC=C(C=C4)COC(N)=O)=O)=O)=O)CC2)=O)=O
Molecular Formula
C50H81N11O16
Molecular Weight
1092.24
References & Citations
[1]Weeden, Timothy; Hilderbrand, Scott; Spring, Sean; Shen, Peiyi; Vieira, Benjamin. Methods of preparing protein-oligonucleotide complexes. WO2022051665A1
Shipping Conditions
Room temperature
Scientific Category
ADC Related
Clinical Information
No Development Reported

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