Basivarsen

• Description:

  Basivarsen (DYNE-101 oligomer) is composed of an antisense oligonucleotides and a linker (HY-177454) . It is designed to target mutant nuclear myotonic dystrophy protein kinase (DMPK) RNA for RHase H-mediated degradation to correct splicing. It is used for the study of myotonic dystrophy type 1 (DM1) .

• Product Name Alternative:

  DYNE-101 oligomer

• UNSPSC:

  12352005

• Target:

  Antibody-Oligonucleotide Conjugates (AOCs)

• Related Pathways:

  Antibody-drug Conjugate/ADC Related

• Field of Research:

  Others

• Smiles:

  [Basivarsen]

• Molecular Formula:

  C228H317N70O107P16S15

• Molecular Weight:

  6726.91

• References & Citations:

  [1]Weeden T, Picariello T, Quinn B, et al. FORCE platform overcomes barriers of oligonucleotide delivery to muscle and corrects myotonic dystrophy features in preclinical models. Commun Med (Lond) . 2025;5 (1) :22.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Oligonucleotides

• Clinical Information:

  Phase 2

• CAS Number:

  [3028750-61-7]