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Camptothecin derivative-3

CAT: 0804-HY-177267Size: 1 EachDry Ice: NoHazardous: No
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Description
Camptothecin derivative-3 (Compound 11) is a derivative of Camptothecin and can serve as a payload for ADCs. Camptothecin derivative-3 has certain cytotoxicity, with IC50 values of 2 nM and 0.9 nM against HSC-2 and Namalwa/luc cells, respectively. Camptothecin derivative-3 can be used in tumor-related research[1].
CAS Number
2378619-11-3
UNSPSC
12352005
Target
ADC Payload; Drug Derivative
Related Pathways
Antibody-drug Conjugate/ADC Related; Others
Applications
Cancer-programmed cell death
Field of Research
Cancer
Solubility
DMSO : 3.85 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
CC[C@@]1(O)C2=C(COC1=O)C(N(CC3=C(C4=CC(C)=C(C=C4N=C35)F)CNC(CO)=O)C5=C2)=O
Molecular Formula
C24H22FN3O6
Molecular Weight
467.45
References & Citations
[1]Li W, et al. Synthesis and Evaluation of Camptothecin Antibody-Drug Conjugates. ACS Med Chem Lett. 2019 Sep 6;10 (10) :1386-1392.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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