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Camptothecin

CAT: 0804-HY-16560-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-16560-01Size:100 mg
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Description
Camptothecin (CPT), a kind of alkaloid, is a DNA topoisomerase I (Topo I) inhibitor with an IC50 of 679 nM[1]. Camptothecin (CPT) exhibits powerful antineoplastic activity against colorectal, breast, lung and ovarian cancers, modulates hypoxia-inducible factor-1α (HIF-1α) activity by changing microRNAs (miRNA) expression patterns in human cancer cells[2][3].
CAS Number
7689-03-4
Product Name Alternative
Campathecin; (S) - (+) -Camptothecin; CPT
UNSPSC
12352005
Hazard Statement
H301, H340
Target
ADC Payload; Antibiotic; Apoptosis; Fungal; Influenza Virus; MicroRNA; Topoisomerase
Type
Natural Products
Related Pathways
Antibody-drug Conjugate/ADC Related; Anti-infection; Apoptosis; Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer; Infection
Assay Protocol
https://www.medchemexpress.com/Campathecin.html
Purity
99.86
Solubility
1M NaOH : 10 mg/mL (ultrasonic; adjust pH to 11 with NaOH) |DMSO : 6.25 mg/mL (ultrasonic)
Smiles
O=C1C2=C([C@@](O)(CC)C(OC2)=O)C=C(N1C3)C(C3=C4)=NC5=C4C=CC=C5
Molecular Formula
C20H16N2O4
Molecular Weight
348.36
Precautions
H301, H340
References & Citations
[1]Luzzio MJ, et al. Synthesis and antitumor activity of novel water soluble derivatives of camptothecin as specific inhibitors of topoisomerase I. Synthesis and antitumor activity of novel water soluble derivatives of camptothecin as specific inhibitors of topoisomerase I.|[2]Bertozzi D, et al. The natural inhibitor of DNA topoisomerase I, camptothecin, modulates HIF-1α activity by changing miR expression patterns in human cancer cells. Mol Cancer Ther. 2014;13 (1) :239-248.|[3]Schön M, et al. KINK-1, a novel small-molecule inhibitor of IKKbeta, and the susceptibility of melanoma cells to antitumoral treatment. J Natl Cancer Inst. 2008;100 (12) :862-875..|[4]Huang Q, et al. Evolution in medicinal chemistry of E-ring-modified Camptothecin analogs as anticancer agents. Eur J Med Chem. 2013;63:746-757.|[5]Tesauro C, et al. Topoisomerase I activity and sensitivity to camptothecin in breast cancer-derived cells: a comparative study. BMC Cancer. 2019;19 (1) :1158. Published 2019 Nov 29.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
Launched
Isoform
Camptothecins; Topo I

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abx182718-01(+)-Camptothecin

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