ALK2-IN-6

• Description:

  ALK2-IN-6 (Compound 14a) is a selective ALK2 inhibitor, with an IC50 of 9 nM. ALK2-IN-6 can be used in the research of diffuse intrinsic pontine glioma[1].

• UNSPSC:

  12352005

• Target:

  TGF-β Receptor

• Related Pathways:

  TGF-beta/Smad

• Field of Research:

  Cancer

• Smiles:

  CN(CC1)CCN1C(C=C2)=CC=C2C3=C(C)C(C4=CC(OC)=C(C(OC)=C4)OC)=CN=C3

• Molecular Formula:

  C26H31N3O3

• Molecular Weight:

  433.54

• References & Citations:

  [1]Smil D, et al. Leveraging an Open Science Drug Discovery Model to Develop CNS-Penetrant ALK2 Inhibitors for the Treatment of Diffuse Intrinsic Pontine Glioma. J Med Chem. 2020 Sep 10;63 (17) :10061-10085.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  ALK2

• CAS Number:

  2600795-23-9