ALK2-IN-6

• Description :

  ALK2-IN-6 (Compound 14a) is a selective ALK2 inhibitor, with an IC50 of 9 nM. ALK2-IN-6 can be used in the research of diffuse intrinsic pontine glioma[1].

• CAS Number :

  [2600795-23-9]

• UNSPSC :

  12352005

• Target :

  TGF-β Receptor

• Related Pathways :

  TGF-beta/Smad

• Field of Research :

  Cancer

• Smiles :

  CN(CC1)CCN1C(C=C2)=CC=C2C3=C(C)C(C4=CC(OC)=C(C(OC)=C4)OC)=CN=C3

• Molecular Formula :

  C26H31N3O3

• Molecular Weight :

  433.54

• References & Citations :

  [1]Smil D, et al. Leveraging an Open Science Drug Discovery Model to Develop CNS-Penetrant ALK2 Inhibitors for the Treatment of Diffuse Intrinsic Pontine Glioma. J Med Chem. 2020 Sep 10;63 (17) :10061-10085.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  ALK2