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ALK2-IN-2

CAT: 0804-HY-112815-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-112815-01Size:5 mg
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Description
ALK2-IN-2 is an orally active and selective inhibitor of ALK2 (ACVR1), with an IC50 value of 9 nM, and over 700-fold selectivity against ALK3. ALK2-IN-2 can inhibit oxidative stress and protect endothelial cells[1][2].
CAS Number
[2254409-25-9]
UNSPSC
12352005
Target
TGF-β Receptor
Type
Reference compound
Related Pathways
TGF-beta/Smad
Applications
Neuroscience-Neuromodulation
Field of Research
Inflammation/Immunology; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/alk2-in-2.html
Concentration
10mM
Purity
99.93
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
CC(N1CCCC1)C(C=C2)=CC=C2C(C=N3)=CN4C3=C(C5=CC=C(S(=O)(N)=O)C6=C5C=CC=C6)C=N4
Molecular Formula
C28H27N5O2S
Molecular Weight
497.61
References & Citations
[1]Jiang JK, et al. Discovery of 3- (4-sulfamoylnaphthyl) pyrazolo[1,5-a]pyrimidines as potent and selective ALK2 inhibitors. Bioorg Med Chem Lett. 2018 Nov 1;28 (20) :3356-3362.|[2]Cao C, et al. Circulating exosomes repair endothelial cell damage by delivering miR-193a-5p. J Cell Mol Med. 2021 Feb;25 (4) :2176-2189.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
ALK2

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A13604-50ALK2-IN-2 50mg
A13604-200ALK2-IN-2 200mg
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