ALK2-IN-2

• Description :

  ALK2-IN-2 is an orally active and selective inhibitor of ALK2 (ACVR1), with an IC50 value of 9 nM, and over 700-fold selectivity against ALK3. ALK2-IN-2 can inhibit oxidative stress and protect endothelial cells[1][2].

• UNSPSC :

  12352005

• Target :

  TGF-β Receptor

• Type :

  Reference compound

• Related Pathways :

  TGF-beta/Smad

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Inflammation/Immunology; Cardiovascular Disease

• Assay Protocol :

  https://www.medchemexpress.com/alk2-in-2.html

• Concentration :

  10mM

• Purity :

  99.93

• Solubility :

  DMSO : 125 mg/mL (ultrasonic)

• Smiles :

  CC(N1CCCC1)C(C=C2)=CC=C2C(C=N3)=CN4C3=C(C5=CC=C(S(=O)(N)=O)C6=C5C=CC=C6)C=N4

• Molecular Formula :

  C28H27N5O2S

• Molecular Weight :

  497.61

• References & Citations :

  [1]Jiang JK, et al. Discovery of 3- (4-sulfamoylnaphthyl) pyrazolo[1,5-a]pyrimidines as potent and selective ALK2 inhibitors. Bioorg Med Chem Lett. 2018 Nov 1;28 (20) :3356-3362.|[2]Cao C, et al. Circulating exosomes repair endothelial cell damage by delivering miR-193a-5p. J Cell Mol Med. 2021 Feb;25 (4) :2176-2189.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  ALK2

• CAS Number :

  [2254409-25-9]