VVD-849

CAT: 0804-HY-176812Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-176812Size:1 Each
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Description
VVD-849 is a RAS ligand. VVD-849 binds covalently to cysteine 242 in the RAS binding domain of PI3K p110α and promotes RAS/PI3K interaction. VVD-849 partially inhibits pAKT (S473) in HER2 over-expressing tumors. VVD-849 can be used cancers like breast cancer research[1].
CAS Number
[3055321-14-4]
UNSPSC
12352005
Target
PI3K; Ras
Related Pathways
GPCR/G Protein; MAPK/ERK Pathway; PI3K/Akt/mTOR
Field of Research
Cancer
Smiles
ClC1=CC(C2=CC(OCC3=NC=CC=C3)=CC=C2)=C(S(N4CCC(C(N[C@@H](C)/C=C\S(C)(=O)=O)=O)(F)CC4)(=O)=O)C=C1
Molecular Formula
C29H31ClFN3O6S2
Molecular Weight
636.15
References & Citations
[1]Klebba JE, et al. Covalent inhibitors of the RAS binding domain of PI3Kα impair tumor growth driven by RAS and HER2. bioRxiv [Preprint]. 2024 Dec 20:2024.12.17.629001.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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