VVD-849

• Description:

  VVD-849 is a RAS ligand. VVD-849 binds covalently to cysteine 242 in the RAS binding domain of PI3K p110α and promotes RAS/PI3K interaction. VVD-849 partially inhibits pAKT (S473) in HER2 over-expressing tumors. VVD-849 can be used cancers like breast cancer research[1].

• UNSPSC:

  12352005

• Target:

  PI3K; Ras

• Related Pathways:

  GPCR/G Protein; MAPK/ERK Pathway; PI3K/Akt/mTOR

• Field of Research:

  Cancer

• Smiles:

  ClC1=CC(C2=CC(OCC3=NC=CC=C3)=CC=C2)=C(S(N4CCC(C(N[C@@H](C)/C=C\S(C)(=O)=O)=O)(F)CC4)(=O)=O)C=C1

• Molecular Formula:

  C29H31ClFN3O6S2

• Molecular Weight:

  636.15

• References & Citations:

  [1]Klebba JE, et al. Covalent inhibitors of the RAS binding domain of PI3Kα impair tumor growth driven by RAS and HER2. bioRxiv [Preprint]. 2024 Dec 20:2024.12.17.629001.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [3055321-14-4]