RegisterLogin

VVD 065

CAT: 0804-HY-169766Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-169766Size:1 Each
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
VVD 065 is an orally active Keap1-Cul3 Ligands for E3 LigaseMolecular Glues. VVD 065 can activate KEAP1, thereby promoting the degradation of NRF2. VVD 065 can inhibit tumor growth in a non-small cell lung cancer/esophageal squamous cell carcinoma xenograft model. VVD 065 can be used for research on cancers such as non-small cell lung cancer and esophageal squamous cell carcinoma[1].
CAS Number
[3034876-85-9]
UNSPSC
12352101
Target
Keap1-Nrf2; Ligands for E3 Ligase; Molecular Glues
Related Pathways
NF-κB; PROTAC
Field of Research
Cancer
Smiles
C=CC(N1[C@H](C2=CC(C3=NC=NC(N)=N3)=CC(Cl)=C2)COCC1)=O
Molecular Formula
C16H16ClN5O2
Molecular Weight
345.78
References & Citations
[1]Nil Roy, et al. Discovery of VVD-065, a first-in-class allosteric molecular glue of the Keap1-Cul3 E3-ligase complex for the treatment of NRF2-activated cancers. Mol Cancer Ther 1 December 2023; 22 (12_Supplement) : PR011.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Related Products

CatalogName
HY-176811VVD-442
HY-151385-01VVD-118313
HY-173405-01VVD-699
HY-158116-01VVD-214
HY-176812VVD-849
HY-159641-01VVD-130037
HY-151385A-01(R, R) -VVD-118313
HY-P991647ALX-0651
HY-105900Ro 22-0654
HY-100622-01Ro 20-0657/000

Alternative Products

CatalogName
APPDE 300Plasmid DNA Extraction Mini Kit (300prep) (sample size:1~3 ml culture)
APGCK 050GEL/PCR Purification Mini Kit (50prep)
APPCK 200PCR Clean-Up Mini Kit (200prep)
APGPK 200GEL Purification Mini Kit (200prep)
APPGK 100Plant Genomic DNA Extraction Mini Kit (100prep)
APGDC 050FavorPrep Genomic DNA Clean-Up Kit (50prep)
APGDC 200FavorPrep Genomic DNA Clean-Up Kit (200prep)
APVNK 200Viral Nucleic Acid Extraction Kit (200prep), (With Carrier RNA, for low viral load specimen using carrier RNA)
APEBD 002-3Alphagen EtBr Destroyer Sprayer
APRND 001-1Alphagen RNase Destroyer Sprayer

Popular Products