VVD 065

• Description :

  VVD 065 is an orally active Keap1-Cul3 Ligands for E3 LigaseMolecular Glues. VVD 065 can activate KEAP1, thereby promoting the degradation of NRF2. VVD 065 can inhibit tumor growth in a non-small cell lung cancer/esophageal squamous cell carcinoma xenograft model. VVD 065 can be used for research on cancers such as non-small cell lung cancer and esophageal squamous cell carcinoma[1].

• UNSPSC :

  12352101

• Target :

  Keap1-Nrf2; Ligands for E3 Ligase; Molecular Glues

• Related Pathways :

  NF-κB; PROTAC

• Field of Research :

  Cancer

• Smiles :

  C=CC(N1[C@H](C2=CC(C3=NC=NC(N)=N3)=CC(Cl)=C2)COCC1)=O

• Molecular Formula :

  C16H16ClN5O2

• Molecular Weight :

  345.78

• References & Citations :

  [1]Nil Roy, et al. Discovery of VVD-065, a first-in-class allosteric molecular glue of the Keap1-Cul3 E3-ligase complex for the treatment of NRF2-activated cancers. Mol Cancer Ther 1 December 2023; 22 (12_Supplement) : PR011.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [3034876-85-9]