VVD-849

• Target :

  PI3K|||Ras

• Related Pathways :

  PI3K/Akt/mTOR signaling|||MAPK

• Bioactivity :

  VVD-849 is a RAS ligand that covalently binds to cysteine at position 242 within the RAS binding domain of PI3Kp110?, enhancing RAS/PI3K interaction. It partially inhibits pAKT (S473) in tumors overexpressing HER2. VVD-849 is applicable in cancer research, including studies on breast cancer.

• Smiles :

  S(=O)(=O)(C1=C(C=C(Cl)C=C1)C2=CC(OCC3=CC=CC=N3)=CC=C2)N4CCC(C(N[C@H](/C=C\S(C)(=O)=O)C)=O)(F)CC4

• Molecular Formula :

  C29H31ClFN3O6S2

• Molecular Weight :

  636.15

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  3055321-14-4