VVD-849

CAT: 0931-T212213-01Size: 10 mgDry Ice: NoHazardous: No
CAT#:0931-T212213-01Size:10 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
3055321-14-4
Target
PI3K|||Ras
Related Pathways
PI3K/Akt/mTOR signaling|||MAPK
Bioactivity
VVD-849 is a RAS ligand that covalently binds to cysteine at position 242 within the RAS binding domain of PI3Kp110?, enhancing RAS/PI3K interaction. It partially inhibits pAKT (S473) in tumors overexpressing HER2. VVD-849 is applicable in cancer research, including studies on breast cancer.
Smiles
S(=O)(=O)(C1=C(C=C(Cl)C=C1)C2=CC(OCC3=CC=CC=N3)=CC=C2)N4CCC(C(N[C@H](/C=C\S(C)(=O)=O)C)=O)(F)CC4
Molecular Formula
C29H31ClFN3O6S2
Molecular Weight
636.15
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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